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- Primary Malignant Melanoma of the Breast: A Report of Two Cases
- Jiwon Koh, Jihyeon Lee, So Youn Jung, Han Sung Kang, Tak Yun, Youngmee Kwon
- J Pathol Transl Med. 2019;53(2):119-124. Published online November 26, 2018
- DOI: https://doi.org/10.4132/jptm.2018.10.18
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- 168 Download
- 5 Web of Science
- 6 Crossref
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Abstract
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Supplementary Material - Primary malignant melanoma of the breast (PMMB) is a rare tumor with only a few case reports available in the literature. We report two cases of PMMB, one derived from the breast parenchyma and the other from the breast skin. The first case consisted of atypical epithelioid cells without overt melanocytic differentiation like melanin pigments. The tumor cells showed diffuse positivity for S100 protein, tyrosinase, and BRAF V600E. However, the tumor cells were negative for cytokeratin, epithelial membrane antigen, and HMB-45. The second case showed atypical melanocytic proliferation with heavy melanin pigmentation. The tumor cells were positive for S100 protein, HMB-45, tyrosinase, and BRAF V600E. These two cases represent two distinct presentations of PMMB in terms of skin involvement, melanin pigmentation, and HMB-45 positivity. Although PMMB is very rare, the possibility of this entity should be considered in malignant epithelioid neoplasms in the breast parenchyma.
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Citations
Citations to this article as recorded by
- Primary Malignant Melanoma of the Breast Presenting as a Breast Abscess: A Case Report
Hyung In Choi, You Me Kim, Junwon Min, Yong Moon Lee, Hee Jeong Kim
Journal of the Korean Society of Radiology.2023; 84(3): 763. CrossRef - Case Report: Care Report: Primary malignant melanoma of the breast
Juee Meghe, Yeshwant Lamture, Varsha Gajhbhiye, Pankaj Gharde, Akash Inamdar
F1000Research.2023; 12: 1323. CrossRef - Series of rare cases of breast tumour: 8-year review at mankweng Breast Oncology clinic, Limpopo, South Africa
Mirza M. Z. U. Bhuiyan
EUREKA: Health Sciences.2023; (4): 3. CrossRef - Malignant melanoma of the breast: controversies in the diagnosis and therapeutic management of a rare nosologic entity
Aikaterini Mastoraki, Dimitrios Schizas, Ilias Giannakodimos, Athanasios Rebakos, Ioannis Margaris, Ioannis Katsaros, Ilias Vagios, Pantelis Vassiliu, Emmanouil Pikoulis
International Journal of Dermatology.2020; 59(9): 1057. CrossRef - Uncommon Subtypes of Malignant Melanomas: A Review Based on Clinical and Molecular Perspectives
Matías Chacón, Yanina Pfluger, Martín Angel, Federico Waisberg, Diego Enrico
Cancers.2020; 12(9): 2362. CrossRef - Primary Melanoma of the Breast Parenchyma: An Oncoplastic Approach
Emma Snashall, Tamara Kiernan, Aenone Harper-Machin, Rieka Taghizadeh
Plastic and Reconstructive Surgery - Global Open.2020; 8(12): e3276. CrossRef
- Primary Malignant Melanoma of the Breast Presenting as a Breast Abscess: A Case Report
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